Kisspeptin-10

Third-Party Tested

Independent lab verified

Batch-Specific CoA

Publicly accessible

YPB.266

Reference number

10mg

Lyophilized vial

Origin

Kisspeptin was originally identified as metastin, a metastasis-suppressing peptide encoded by the KISS1 gene, discovered by Lee et al. at the Penn State College of Medicine in 1996. Its role in reproductive neuroendocrinology was recognized in 2003 when mutations in the kisspeptin receptor GPR54 were found to cause hypogonadotropic hypogonadism.

Research Lineage

de Roux et al. and Seminara et al. independently published the link between GPR54 mutations and pubertal failure in 2003. Dhillo et al. at Imperial College London conducted the first human administration studies, demonstrating potent GnRH-stimulating effects. Kisspeptin-10 is the minimal active fragment retaining full GPR54 agonist activity.

Mechanism of Action

Kisspeptin-10 binds to the GPR54 receptor (KISS1R) on GnRH neurons in the hypothalamus, stimulating GnRH release which drives LH and FSH secretion from the pituitary. It is considered the most potent known upstream activator of the reproductive hormone cascade. In research models, it has been used to probe the hypothalamic-pituitary-gonadal axis without direct gonadotropin administration.

Structural Notes

Decapeptide. C-terminal fragment of kisspeptin-54 (residues 112-121). Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2. Molecular weight: 1302.45 Da.