GHRP-6
GHRP-6 (10mg / 5mg)
Vial Size
$110USD
Third-Party Tested
Independent lab verified
Batch-Specific CoA
Publicly accessible
YPB.282
Reference number
5mg
Lyophilized vial
Growth Hormone Releasing Peptide 6. Synthetic met-enkephalin analog that stimulates GH release via ghrelin receptor activation.
Origin
GHRP-6 was one of the first synthetic growth hormone secretagogues, developed by Cyril Bowers and colleagues at Tulane University in the 1980s. It emerged from systematic modifications of met-enkephalin that were found to stimulate GH release independent of the opioid receptor pathway.
Research Lineage
Bowers' work on GHRP-6 was instrumental in the discovery of the growth hormone secretagogue receptor (GHS-R), later identified as the ghrelin receptor by Kojima et al. in 1999. The compound has been extensively used as a pharmacological tool in neuroendocrine research. Over 500 publications reference GHRP-6 in GH axis and metabolic studies.
Mechanism of Action
GHRP-6 activates the GHS-R1a receptor on pituitary somatotrophs and hypothalamic neurons, stimulating GH release through a pathway complementary to GHRH. Unlike Ipamorelin, GHRP-6 also activates the HPA axis and stimulates appetite through ghrelin-mimetic effects. It has been observed to increase ACTH, cortisol, and prolactin at higher concentrations.
Structural Notes
Hexapeptide. Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2. Molecular weight: 873.01 Da.
Key References
Bowers CY et al. Endocrinology. 1984;114(5):1537-45.
Kojima M et al. Nature. 1999;402(6762):656-60.
Research Use Only. This product is intended for laboratory research purposes only. Not for human or veterinary use. Not for sale to minors.