Thymalin

Third-Party Tested

Independent lab verified

Batch-Specific CoA

Publicly accessible

YPB.280

Reference number

10mg

Lyophilized vial

Origin

Thymalin is a polypeptide complex extracted from calf thymus glands, developed as part of the Soviet bioregulation research program by Khavinson and Morozov at the Military Medical Academy in Leningrad (now Saint Petersburg) beginning in the 1970s. It was one of the first peptide bioregulators to be registered as a pharmaceutical in Russia.

Research Lineage

Khavinson and Morozov published long-term human studies in elderly populations, observing effects on immune markers and mortality rates over 6-8 year follow-up periods. Thymalin has been registered and used clinically in Russia since the 1980s. It represents the whole-extract predecessor to the purified synthetic peptides (like Epitalon) that followed.

Mechanism of Action

As a complex mixture of thymic peptides, Thymalin's mechanism involves multiple components acting on T-cell maturation and differentiation. It has been observed to normalize T-cell subpopulation ratios and modulate cytokine production in immunocompromised animal models. Unlike purified single-peptide preparations, it contains a spectrum of bioactive fragments from the thymus.

Structural Notes

Polypeptide complex. Contains a mixture of peptide fragments extracted from calf thymus, standardized by biological activity. Not a single defined sequence.