Epitalon
Epitalon (10mg / 50mg)
Vial Size
$150USD
Third-Party Tested
Independent lab verified
Batch-Specific CoA
Publicly accessible
YPB.254
Reference number
50mg
Lyophilized vial
Synthetic tetrapeptide derived from pineal gland extract Epithalamin. Studied extensively by Professor Vladimir Khavinson.
Origin
Epitalon (also Epithalon, AEDG peptide) is a synthetic tetrapeptide developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology in the 1990s. It was designed as a synthetic analog of Epithalamin, a polypeptide extract from bovine pineal glands that Khavinson had studied since the 1970s under the Soviet bioregulation program.
Research Lineage
Khavinson and colleagues have published over 200 papers on Epitalon and the broader class of short regulatory peptides (bioregulators). Anisimov et al. conducted lifespan studies in rodent models. Research has focused on telomere biology, circadian rhythm regulation, and antioxidant enzyme expression. The peptide is central to the Russian school of peptide bioregulation.
Mechanism of Action
Epitalon has been observed to activate telomerase (hTERT) expression in human somatic cell cultures, leading to telomere elongation in studies by Khavinson et al. It has also been investigated for its effects on melatonin synthesis in pinealocyte cultures and for modulation of antioxidant enzyme expression. The proposed mechanism involves direct interaction with DNA through the minor groove, influencing gene transcription.
Structural Notes
Tetrapeptide. Sequence: Ala-Glu-Asp-Gly. Molecular weight: 390.35 Da.
Key References
Khavinson VK et al. Bull Exp Biol Med. 2003;135(6):590-2.
Anisimov VN et al. Biogerontology. 2003;4(4):193-202.
Research Use Only. This product is intended for laboratory research purposes only. Not for human or veterinary use. Not for sale to minors.