MOTS-c
MOTS-c (10mg / 40mg)
Vial Size
$200USD
Third-Party Tested
Independent lab verified
Batch-Specific CoA
Publicly accessible
YPB.271
Reference number
40mg
Lyophilized vial
Mitochondrial-derived peptide encoded by the 12S rRNA gene. Studied for metabolic regulation and cellular homeostasis.
Origin
MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) was discovered by Changhan Lee and Pinchas Cohen at the University of Southern California in 2015. It was identified through computational analysis of alternative open reading frames within the mitochondrial 12S rRNA gene — a novel concept that mitochondrial DNA encodes bioactive peptides beyond the 13 established proteins.
Research Lineage
Lee et al. published the discovery in Cell Metabolism in 2015, demonstrating metabolic effects in mouse models. Cohen's laboratory has subsequently characterized MOTS-c in exercise physiology, aging, and metabolic stress research. Reynolds et al. found that MOTS-c translocates to the nucleus under stress conditions, suggesting a role in retrograde mitochondrial signaling.
Mechanism of Action
MOTS-c has been observed to activate AMPK (AMP-activated protein kinase) and regulate the folate-methionine cycle, influencing de novo purine synthesis. Under metabolic stress, it translocates from the cytoplasm to the nucleus where it interacts with antioxidant response element (ARE) transcription factors. In preclinical models, it has been investigated for effects on insulin sensitivity and fat metabolism.
Structural Notes
16-amino-acid peptide. Encoded within the mitochondrial 12S rRNA gene. Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg. Molecular weight: 2174.64 Da.
Key References
Lee C et al. Cell Metab. 2015;21(3):443-54.
Reynolds JC et al. Cell Metab. 2021;33(3):651-69.
Research Use Only. This product is intended for laboratory research purposes only. Not for human or veterinary use. Not for sale to minors.